When you think of PMS or Premenstrual Syndrome, you may think at first that it is all about hormones, but there is more to it than that.
Hormones are just one part of the story.
But first, what is PMS?
PMS or premenstrual syndrome is a combination of symptoms just before menstruation in many menstrual women.
Most menstrual periods have some form of PMS and these can be physical or emotional symptoms. And women in their 30s and 40s are more likely to have worse symptoms of PMS.
Physical symptoms may include cramping, headache, bloating, tender breasts, and constipation. And the psychological symptoms of PMS include nausea, anxiety, stress, gloominess and mood swings.
PMS occurs after ovulation and before the onset of menstruation. Researchers believe that PMS occurs immediately after ovulation because levels of the hormones progesterone and estrogen begin to decline. And then when the hormone levels start to rise, the symptoms of PMS start to spread.
So are hormones a part of PMS?
Yes, these are part of the ups and downs of a woman’s premenstrual syndrome, but they are only part of the story behind PMS.
New scientific research shows that hormones indicate the time of PMS, they are not the underlying cause behind physical and mental symptoms. In fact there is a study where there is no difference in hormone levels in those who experience severe PMS symptoms and those who have no symptoms on the opposite side (Biggs, 2011).
A new theory has emerged that assumes that glucose is metabolized in the brain and that triglycerides are the cause of the rise and fall of at least some of the psychological symptoms of PMS.
In a 2015 study, scientists found an unusually large spike in glucose in the cerebellum when women were experiencing PMS. And then, there was no glucose spike for women who did not experience PMS (Liu, 2015).
What does glucose actually mean with PMS?
With a spike in glucose in the brain, this means more energy is needed. And when the cerebellum does not get enough glucose, it is when someone experiences anxiety and mood swings that occur during PMS (Schmahmann, 2019).
So during PMS, the brain needs more energy to function properly and if it doesn’t get all the energy it needs, it goes into anxiety, mood swings, PMS mode. So, at this time of the month the brain needs to bring more energy.
OAA may be the solution
OAA or oxaloacetate supplements interact with PMS in a way that supports glucose in the brain.
As part of the Krebs cycle, OAA is an important factor in how our cells convert glucose into the energy they need.
GABA is a neurotransmitter found in the brain and its primary function is to relieve anxiety and improve mood. At the same time, there is another neurotransmitter, glutamine, which causes excessive stimulation of brain cells when it is in excess in the brain, and scientists have discovered that the GABA system is less active during menstruation with severe PMS. Leading to menstruation (Liu, 2015).
So in a 2014 study, scientists discovered that OAA supplements support the brain’s ability to balance by effectively regulating GABA and glutamate levels to support healthy brain function.
Where can you find OAA supplements?
Oxaloacetate is notoriously difficult to keep stable, but finally there is a new OAA supplement that does just that. The biotech company, Terra Biological, has developed Jubilance for PMS, a supplement to OAA to help control glucose in the brain during PMS (Tully, 2020).
This OAA supplement is the first of its kind and clinically proven in two double-blind, placebo-controlled, cross-over design and peer-reviewed studies that have improved PMS-related anxiety and glomeruli more than 50%.
Hormones are just part of the description of how to help women with their PMS symptoms. Fortunately, there is now a solution behind this, including a clinical trial.